A New Way to Read the Genome

I am pleased to announce that earlier today the embargo was lifted on our most recent paper. This work represents the culmination of over two years of effort by my collaborators and I. You can find the official version on the Nature Genetics website here, and the freely available ReadCube version here. In this post, I will focus on making the science accessible to the lay reader. I have also written another post, The Quantified Anatomy of a Paper, which delves into the quantified-self analytics of this project.

CASP10, and the Future of Structure in Biology

I recently had the fortune of attending the 10th Community Assessment of protein Structure Prediction, or CASP, as it is affectionately known. CASP is a competition of sorts that happens once every two years to ascertain the progress made in computationally predicting protein structure. It is a blind experiment, where the structures to be predicted are unknown beforehand, and thus serves as a unbiased test of the predictive power of current computational methods. It is in many ways a model that the rest of computational biology ought (and is starting) to follow.